Title: Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase
Authors: Vanheusden, V ×
Munier-Lehmann, H
Froeyen, Mathy
Busson, Roger
Rozenski, Jef
Herdewijn, Piet
Van Calenbergh, S #
Issue Date: 2004
Series Title: Journal of Medicinal Chemistry vol:47 issue:25 pages:6187-6194
Abstract: Thymidine monophosphate kinase of Mycobacterium tuberculosis (TMPKmt) represents an attractive target for selectively blocking bacterial DNA synthesis. Hereby, we report on the discovery of a novel class of bicyclic nucleosides (10 and 11) and one dinucleoside (12), belonging to the most selective inhibitors of TMPKmt discovered so far.
ISSN: 0022-2623
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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