Title: Antibiotic prophylaxis for children with primary vesicoureteral reflux: where do we stand today?
Authors: Costers, Michiel ×
Lombaerts, Rita
Levtchenko, Elena
Bogaert, Guy #
Issue Date: 29-Jul-2008
Publisher: Hindawi Publishing Corp.
Series Title: Advances in Urology issue:epub
Article number: 217805
Abstract: The main goal of the management of vesicoureteral reflux (VUR) is prevention of recurrent urinary tract infections (UTIs), and thereby prevention of renal parenchymal damage possibly ensuing from these infections. Long-term antibiotic prophylaxis is common practice in the management of children with VUR, as recommended in 1997 in the guidelines of the American Urological Association. We performed a systematic review to ascertain whether antibiotics can be safely discontinued in children with VUR and whether prophylaxis is effective in the prevention of recurrent UTIs and renal damage in these patients. Several uncontrolled studies indicate that antibiotic prophylaxis can be discontinued in a subset of patients, that is, school-aged children with low-grade VUR, normal voiding patterns, kidneys without hydronephrosis or scars, and normal anatomy of the urogenital system. Furthermore, a few recent randomized controlled trials suggest that antibiotic prophylaxis offers no advantage over intermittent antibiotic therapy of UTIs in terms of prevention of recurrent UTIs or new renal damage.
ISSN: 1687-6369
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Urology Section (-)
Laboratory of Pediatric Immunology
Section Child - Miscellaneous (-)
× corresponding author
# (joint) last author

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