Title: Synthesis and hybridization properties of inverse oligonucleotides
Authors: Marangoni, M ×
Van Aerschot, Arthur
Augustijns, Patrick
Rozenski, Jef
Herdewijn, Piet #
Issue Date: Aug-1997
Series Title: Nucleic acids research vol:25 issue:15 pages:3034-3041
Abstract: The synthesis of adenine and thymine cyclopentylethyl nucleosides is presented. This novel constrained monomeric building block is very difficult to incorporate into oligonucleotides. It was introduced in 13mer oligodeoxynucleotide sequences at a single position using H-phosphonate chemistry. Phosphoramidite chemistry completely failed in this particular case. The H-phosphonate building blocks were obtained starting from the corresponding phosphoramidites. Stability of duplexes with RNA and DNA is significantly reduced.
ISSN: 0305-1048
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
Drug Delivery and Disposition
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
1997-Marangoni-Synthesis and hybridization properties...- Nucleic Acids Res.pdf Published 132KbAdobe PDFView/Open


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science