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Title: Optimized methods for capillary electrophoresis of tetracyclines
Authors: Li, Y M ×
Van Schepdael, Ann
Roets, Eugene
Hoogmartens, Jos #
Issue Date: May-1997
Series Title: Journal of pharmaceutical and biomedical analysis vol:15 issue:8 pages:1063-9
Abstract: Optimized methods for the analysis of some tetracyclines by capillary electrophoresis are described. Different buffer systems were employed for the separation of tetracycline, oxytetracycline and demeclocycline from their respective major impurities, including the 2-acetyl-2-decarboxamido derivatives. The influence of buffer pH and buffer concentration was systematically investigated. Non-ionic surfactant Triton X-100 and methyl-beta-cyclodextrin were used to obtain improved selectivity in the case of oxytetracycline and demeclocycline. The results are compared with those of previously established liquid chromatography methods. Good correlations were obtained.
ISSN: 0731-7085
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmaceutical Analysis
× corresponding author
# (joint) last author

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