Title: Incorporation of a disaccharide nucleoside into the backbone of double-stranded DNA: crystallization and preliminary X-ray diffraction
Authors: Van Hecke, Kristof ×
Uytterhoeven, Koen
Mikhailov, SN
Herdewijn, Piet
Van Meervelt, Luc #
Issue Date: 2005
Series Title: Acta crystallographica. Section F, Structural biology and crystallization communications vol:61 issue:Pt 10 pages:953-955
Abstract: Incorporation of a disaccharide nucleoside into double-stranded DNA can be considered as a chemical (non-enzymatic) alternative for site-specific cleavage of DNA. Crystals of the sequence d(CGCGAATT*CGCG), where * is an incorporated ribose, were obtained by hanging-drop vapour diffusion and diffracted to 2.6 A. The crystals belong to the orthorhombic space group P222(1), with unit-cell parameters a = 41.52, b = 57.63, c = 81.39 A, indicating a new crystal packing motif for an oligonucleotide dodecamer sequence.
ISSN: 1744-3091
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Imaging and Photonics
Tutorial services, Faculty of Science
Medicinal Chemistry (Rega Institute)
Biochemistry, Molecular and Structural Biology Section
× corresponding author
# (joint) last author

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