Title: Pseudouridine detection improvement by derivatization with methyl vinyl sulfone and capillary HPLC-mass spectrometry
Authors: Emmerechts, Gert ×
Herdewijn, Piet
Rozenski, Jef #
Issue Date: 2005
Series Title: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences vol:825 issue:2 pages:233-238
Abstract: A method is presented for improved detection of pseudouridine in nucleoside mixtures based on the specific derivatization with methyl vinyl sulfone followed by analysis by capillary HPLC-mass spectrometry. Reaction conditions were optimized in order to obtain the best yield and specificity. The method was successfully applied to different nucleoside mixtures.
ISSN: 1570-0232
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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