The US-EU race for world leadership in science and technology has become the favourite subject of recent studies. Studies issued by the European Commission reported the increase of the European share in the world's scientific production and announced world leadership of the EU in scientific output at the end of the last century. In order to be able to monitor those types of global changes, the present study is based on the 15-year period 1991-2005. A set of bibliometric and technometric indicators is used to analyse activity and impact patterns in science and technology output. This set comprises publication output indicators such as (1) the share in the world total, (2) subject-based publication profiles, (3) citation-based indicators like journal-and subject-normalised mean citation rates, (4) international co-publications and their impact as well as (5) patent indicators and publication-patent citation links (both directions). The evolution of national bibliometric profiles, 'scientific weight' and science-technology linkage patterns are discussed as well.