Title: Synthesis and biological evaluation of a technetium-99m(I)-tricarbonyl-labelled phenyltropane derivative
Authors: Kieffer, Davy ×
Cleynhens, Bernard
Vanbilloen, Hubert P
Rattat, Dirk
Terwinghe, Christelle Y
Mortelmans, Luc
Bormans, Guy
Verbruggen, Alfons #
Issue Date: Jan-2006
Publisher: Pergamon Press
Series Title: Bioorganic & Medicinal Chemistry Letters vol:16 issue:2 pages:382-386
Abstract: A new tropane derivative was synthesized by combining a tridentate ligand, N-(2-picolylamine)-N-acetic acid (2-PAA), and a phenyltropane derivative. It was labelled with a [(99m)Tc(CO)(3)](+) moiety, resulting in the formation of two stable and neutral lipophilic isomers. Their identity was confirmed using radio-LC-MS. In normal mice, no brain uptake was observed for any of the isomers and in vitro autoradiography using mouse brain sections showed no specific uptake in the striatal area.
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Radiopharmaceutical Research
Nuclear Medicine & Molecular Imaging
Department of Microbiology & Immunology - miscellaneous
Department of Health and Technology - UC Leuven
× corresponding author
# (joint) last author

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