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Title: Reproductive performance of rats treated with defatted jojoba meal or simmondsin before or during gestation
Authors: Cokelaere, Marnix ×
Daenens, Paul
Decuypere, Eddy
Flo, Gerda
Kühn, Eduard
Van Boven, Maurits
Vermaut, S #
Issue Date: Jan-1998
Publisher: Pergamon
Series Title: Food and Chemical Toxicology vol:36 issue:1 pages:13-9
Abstract: The effects on food intake, growth and reproductive performance parameters of defatted jojoba meal and pure simmondsin, an extract from jojoba meal, were compared in female Wistar rats. Rats fed 0.15% simmondsin or 3% defatted jojoba meal (equivalent to 0.15% simmondsin) for 8 weeks before conception showed a similar reduction in food intake (about 20%) and a similar growth retardation compared with controls. Both treatments induced a reduction in the number of corpora lutea on gestation day 16: this effect could be ascribed to the lower food intake before conception because it was also observed in rats pair-fed to the treated ones. Rats given feed containing 0.15% simmondsin or 3% defatted jojoba meal during days 1-16 of gestation showed a similar reduction in food intake relative to controls. Foetal and placental weights were reduced, relative to controls, to a similar extent in both groups, and the reductions were slightly greater than in the corresponding pair-fed groups. We conclude that the effects on food intake, growth and reproductive performance that were seen after feeding rats defatted jojoba meal were due to the simmondsin content of the meal. The simmondsin induced reduction in food intake and probably also a relative protein shortage.
ISSN: 0278-6915
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Interdisciplinary Research Facility Life Sciences, Campus Kulak Kortrijk
Division of Livestock-Nutrition-Quality (-)
Faculty of Medicine, Campus Kulak Kortrijk
Animal Physiology and Neurobiology Section - miscellaneous
Toxicology and Pharmacology
× corresponding author
# (joint) last author

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