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Title: Evaluation of carbon-11-labelled phenoxy bridged fatty acids for studying myocardial fatty acid metabolism with PET
Authors: de Groot, Tjibbe ×
Maris, Bart
Boonen, Cindy
Bormans, Guy
Mortelmans, Luc
Eisenhut, M
Verbruggen, Alfons #
Issue Date: Jul-1997
Publisher: Pergamon-elsevier science ltd
Series Title: Nuclear medicine and biology vol:24 issue:5 pages:461-464
Abstract: A phenylene moiety in the chain of fatty acids was expected to impair metabolic degradation. Three phenoxy-containing [11C]carboxyl-labelled fatty acids were synthesized and evaluated in mice and an in vivo tissue distribution study. Of these three, 1[11C]-3-(p-dodecyloxyphenyl)propionic acid (C12C3) showed the most favourable uptake in the myocardium: 1.2% of the injected dose at 30 min p.i., vs. 0.6% for [11C]palmitate. The metabolic stability of C12C3 and [11C]palmitate was assessed by determining the amount of exhaled [11C]CO2 during a 30-min interval after injection. It was found that the phenoxy moiety in the gamma-position did not prevent the metabolic degradation of C12C3: After 30 min 20.7% of the injected dose was exhaled as [11C]CO2 vs. 12.7% for [11C]palmitate.
ISSN: 0969-8051
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Radiopharmaceutical Research
Drug Delivery and Disposition
Nuclear Medicine & Molecular Imaging
× corresponding author
# (joint) last author

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