Title: Substrate specificity of penicillin acylase of E. coli
Authors: Plaskie, A ×
Roets, Eugene
Vanderhaeghe, Hubert #
Issue Date: 1978
Publisher: Japan antibiot res assn
Series Title: Journal of antibiotics vol:31 issue:8 pages:783-788
Abstract: The hydrolysis of several phenylacetylamino compounds was studied using a purified preparation of E. coli penicillin acylase. The L-isomers of phenylacetyl amino acids were cleaved much faster than the D-isomers. The same observations was made for some phenylacetylamino beta-lactams. When the beta-lactam ring is incorporated in a penam or cephem ring system, the D-isomers were hydrolysed somewhat faster than the L-isomers. We also confirmed that benzylpenicillins with an hydroxy- or an amino-group in alpha-position of the side chain were hydrolysed, both in the normal and the 6-epi-series.
ISSN: 0021-8820
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmaceutical Analysis
Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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