Title: Efficient post-macrocyclization functionalizations of oxacalix[2]arene[2]pyrimidines
Authors: Van Rossom, Wim ×
Maes, Wouter
Kishore, Lingam
Ovaere, Margriet
Van Meervelt, Luc
Dehaen, Wim #
Issue Date: Feb-2008
Publisher: Amer chemical soc
Series Title: Organic letters vol:10 issue:4 pages:585-588
Abstract: Diversely functionalized oxacalix[2]arene[2]pyrimidines have been synthesized starting from a bis(methylsulfanyl)-substituted oxacalix[4]arene by two efficient post-macrocyclization pathways. Functionalized aryl groups were introduced on the pyrimidine building block via Liebeskind-Srogl cross-coupling reactions, while a variety of O-, S-, N-, and C-nucleophiles were inserted on the calixarene skeleton by nucleophilic aromatic substitution reactions on the bis(methylsulfonyl)oxacalix[4]arene analogue.
ISSN: 1523-7060
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Biochemistry, Molecular and Structural Biology Section
Chemistry - miscellaneous
Molecular Design and Synthesis
× corresponding author
# (joint) last author

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