ITEM METADATA RECORD
Title: Isocratic liquid chromatographic method for the analysis of azithromycin and its structurally related substances in bulk samples
Authors: Kamau, F N ×
Chepkwony, H K
Ngugi, J K
Debremaeker, D
Roets, Eugene
Hoogmartens, Jos #
Issue Date: Oct-2002
Series Title: Journal of chromatographic science vol:40 issue:9 pages:529-33
Abstract: An isocratic liquid chromatographic method with UV detection at 215 nm, which is suitable for the analysis of azithromycin (AZT) in bulk samples, is described. AZT is separated from its synthesis intermediates and a degradation product as well as from six unknown impurities on an XTerra RP18 column at 70 degrees C using a mobile phase consisting of acetonitrile-pH 6.5 0.2M K2HPO4-water (35:10:55, v/v/v) at 1.0 mL/min. The XTerra stationary phase contains methyl groups that are incorporated in the bulk structure of the material. This allows for special selectivities. Robustness is evaluated by a full factorial design experiment. The method shows good selectivity, repeatability, linearity, and sensitivity.
URI: 
ISSN: 0021-9665
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmaceutical Analysis
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy

 




All items in Lirias are protected by copyright, with all rights reserved.

© Web of science