Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-N,N-dimethylamino benzo[b]furan derivatives as inhibitors of tubulin polymerization
Romagnoli, Romeo × Baraldi, Pier Giovanni Sarkar, Taradas Carrion, Maria Dora Cruz-Lopez, Olga Lopez Cara, Carlota Tolomeo, Manlio Grimaudo, Stefania Di Cristina, Antonietta Pipitone, Maria Rosaria Balzarini, Jan Gambari, Roberto Ilaria, Lampronti Saletti, Roberto Brancale, Andrea Hamel, Ernest #
Molecules that target microtubules have an important role in the treatment of cancer. A new class of inhibitors of tubulin polymerization based on the 2-(3,4,5-trimethoxybenzoyl)-2-dimethylamino-benzo[b]furan molecular skeleton was synthesized and evaluated for antiproliferative activity, inhibition of tubulin polymerization, and cell cycle effects. The most promising compound in this series was 2-(3,4,5-trimethoxybenzoyl)-3-dimethylamino-6-methoxy-benzo[b]furan, which inhibits cancer cell growth at nanomolar concentrations and interacts strongly with tubulin by binding to the colchicine site.