Title: Static headspace gas chromatography of (semi-)volatile drugs in pharmaceuticals for topical use
Authors: Sitaramaraju, Yarramraju
van Hul, Ariane
Wolfs, Kris
Van Schepdael, Ann
Hoogmartens, Jos
Adams, Erwin # ×
Issue Date: Aug-2008
Publisher: Pergamon-elsevier science ltd
Series Title: Journal of pharmaceutical and biomedical analysis vol:47 issue:4-5 pages:834-840
Abstract: An analytical method that allows simultaneous analysis of some (semi-)volatile drugs and additives in pharmaceuticals for topical use was developed using classical static headspace as sampling technique combined with gas chromatography (HS-GC). The capillary column used, RSL-200, showed good selectivity towards all the analytes in the samples investigated. Among the different dilution media investigated, dimethyl sulfoxide in combination with sodium chloride solution showed better sensitivity. Using the optimized headspace sample dilution medium, better sensitivities for all the analytes were achieved at low thermostatting temperature (85 degrees C). The optimized HS-GC method with flame ionization detection showed good repeatability, linearity and accuracy. (c) 2008 Elsevier B.V. All rights reserved.
ISSN: 0731-7085
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmaceutical Analysis
× corresponding author
# (joint) last author

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