Title: Finding an alternative column for the separation of antibiotics on XTerra RP using a column classification system
Authors: Haghedooren, Erik
Koczian, Kristof
Huang, Shan
Dragovic, Sanja
Noszal, Bela
Hoogmartens, Jos
Adams, Erwin # ×
Issue Date: 2008
Publisher: Taylor & francis inc
Series Title: Journal of liquid chromatography & related technologies vol:31 issue:8 pages:1081-1103
Abstract: A project to develop a test procedure to characterize reversed-phase liquid chromatographic C18 columns was started earlier and resulted in a fast, simple, repeatable, and reproducible test procedure. In this paper, the separations of two antibiotics (erythromycin and tetracycline) from their respective impurities were examined. Both methods were developed on XTerra RP, a hybrid column. The performance of the column classification system was evaluated by finding an alternative column for the XTerra RP column. The column classification system was helpful in the selection of a suitable column for the separation of erythromycin, but also showed its limitations towards the separation of tetracycline. The addition of an efficiency parameter and/or omission of one of the original parameters did not improve the results.
ISSN: 1082-6076
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmaceutical Analysis
× corresponding author
# (joint) last author

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