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Title: Multipotent adult progenitor cells sustain function of ischemic limbs in mice
Authors: Lopez Aranguren, Xabier
McCue, Jonathan D
Hendrickx, Benoit
Zhu, Xiao-Hong
Du, Fei
Chen, Eleanor
Pelacho, Beatriz
Peñuelas, Ivan
Abizanda, Gloria
Uriz, Maialen
Frommer, Sarah A
Ross, Jeffrey J
Schroeder, Betsy A
Seaborn, Meredith S
Adney, Joshua R
Hagenbrock, Julianna
Harris, Nathan H
Zhang, Yi
Zhang, Xiaoliang
Nelson-Holte, Molly H
Jiang, Yuehua
Billiau, An
Chen, Wei
Prósper, Felipe
Verfaillie, Catherine
Luttun, Aernout # ×
Issue Date: Feb-2008
Publisher: American Society for Clinical Investigation
Series Title: Journal of Clinical Investigation vol:118 issue:2 pages:505-514
Abstract: Despite progress in cardiovascular research, a cure for peripheral vascular disease has not been found. We compared the vascularization and tissue regeneration potential of murine and human undifferentiated multipotent adult progenitor cells (mMAPC-U and hMAPC-U), murine MAPC-derived vascular progenitors (mMAPC-VP), and unselected murine BM cells (mBMCs) in mice with moderate limb ischemia, reminiscent of intermittent claudication in human patients. mMAPC-U durably restored blood flow and muscle function and stimulated muscle regeneration, by direct and trophic contribution to vascular and skeletal muscle growth. This was in contrast to mBMCs and mMAPC-VP, which did not affect muscle regeneration and provided only limited and transient improvement. Moreover, mBMCs participated in a sustained inflammatory response in the lower limb, associated with progressive deterioration in muscle function. Importantly, mMAPC-U and hMAPC-U also remedied vascular and muscular deficiency in severe limb ischemia, representative of critical limb ischemia in humans. Thus, unlike BMCs or vascular-committed progenitors, undifferentiated multipotent adult progenitor cells offer the potential to durably repair ischemic damage in peripheral vascular disease patients.
URI: 
ISSN: 0021-9738
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Experimental Transplantation
Interdepartemental Stem Cell Institute (-)
Plastic, Reconstructive and Estetic Surgery Section (-)
Molecular and Vascular Biology
× corresponding author
# (joint) last author

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