Title: An acyclic 5-nitroindazole nucleoside analogue as ambiguous nucleoside
Authors: Van Aerschot, Arthur ×
Rozenski, Jef
Loakes, D
Pillet, N
Schepers, G
Herdewijn, Piet #
Issue Date: Nov-1995
Series Title: Nucleic acids research vol:23 issue:21 pages:4363-4370
Abstract: Acyclic nucleoside analogues with carboxamido- or nitro-substituted heterocyclic bases have been evaluated for their possible use as universal bases in oligodeoxynucleotides. The acyclic moiety endows the constructs with enough flexibility to allow good base stacking. The 5-nitroindazole analogue afforded the most stable duplexes among the acyclic derivatives with the least spread in Tm versus the four natural bases. In spite of the acyclic moiety, stabilities are comparable with those of duplexes incorporating the recently described 5-nitroindole nucleoside analogue, but considerably exceed those for the 3-nitropyrrole analogue.
ISSN: 0305-1048
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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