Title: Functional mitochondria are required for alpha-synuclein toxicity in aging yeast
Authors: Büttner, Sabrina
Bitto, Alessandro
Ring, Julia
Augsten, Manuela
Zabrocki, Piotr
Eisenberg, Tobias
Jungwirth, Helmut
Hutter, Sylvia
Carmona-Gutierrez, Didac
Kroemer, Guido
Winderickx, Joris ×
Madeo, Frank #
Issue Date: Mar-2008
Series Title: Journal of Biological Chemistry vol:283 issue:12 pages:7554-7560
Abstract: alpha-Synuclein is one of the principal toxic triggers of Parkinson disease, an age-associated neurodegeneration. Using old yeast as a model of alpha-synuclein expression in post-mitotic cells, we show that alpha-synuclein toxicity depends on chronological aging and results in apoptosis as well as necrosis. Neither disruption of key components of the unfolded protein response nor deletion of proapoptotic key players (including the yeast caspase YCA1, the apoptosis-inducing factor AIF1, or the serine protease OMI) did prevent alpha-synuclein-induced cell killing. However, abrogation of mitochondrial DNA (rho(0)) inhibited alpha-synuclein-induced reactive oxygen species formation and subsequent apoptotic cell death. Thus, introducing an aging yeast model of alpha-synuclein toxicity, we demonstrate a strict requirement of functional mitochondria.
ISSN: 0021-9258
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Physiology of Plants and Micro-organisms Section - miscellaneous
Molecular Genetics Section (-)
Laboratory of Molecular Biology of Leukemia
× corresponding author
# (joint) last author

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