Title: Synthesis and anti-CVB 3 evaluation of substituted 5-nitro-2-phenoxybenzonitriles
Authors: Pürstinger, Gerhard ×
De Palma, Armando
Zimmerhofer, Günther
Huber, Simone
Ladurner, Sophie
Neyts, Johan #
Issue Date: Sep-2008
Publisher: Pergamon Press
Series Title: Bioorganic & Medicinal Chemistry Letters vol:18 issue:18 pages:5123-5125
Abstract: The synthesis and SAR of a series of 60 substituted 2-phenoxy-5-nitrobenzonitriles (analogues of MDL-860) as inhibitors of enterovirus replication (in particular of coxsackievirus B3 (CVB 3)) are reported. Several of the analogues inhibited CVB 3 and other enteroviruses at low-micromolar concentrations.
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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