Author:

Keywords:

Science & Technology, Life Sciences & Biomedicine, Physical Sciences, Chemistry, Medicinal, Chemistry, Organic, Pharmacology & Pharmacy, Chemistry, 5-nitro-2-phenoxybenzonitriles, MDL-860, enterovirus inhibitors, CVB 3, antiviral, 2-(3,4-DICHLOROPHENOXY)-5-NITROBENZONITRILE MDL-860, ENTEROVIRUS INFECTIONS, DILATED CARDIOMYOPATHY, ANTIVIRAL ACTIVITY, PLECONARIL, MYOCARDITIS, VIRUS, PICORNAVIRUSES, INHIBITION, Antiviral Agents, Combinatorial Chemistry Techniques, Enterovirus B, Human, Humans, Molecular Structure, Nitriles, Structure-Activity Relationship, 0304 Medicinal and Biomolecular Chemistry, 0305 Organic Chemistry, 1115 Pharmacology and Pharmaceutical Sciences, Medicinal & Biomolecular Chemistry, 3404 Medicinal and biomolecular chemistry, 3405 Organic chemistry

Abstract:

The synthesis and SAR of a series of 60 substituted 2-phenoxy-5-nitrobenzonitriles (analogues of MDL-860) as inhibitors of enterovirus replication (in particular of coxsackievirus B3 (CVB 3)) are reported. Several of the analogues inhibited CVB 3 and other enteroviruses at low-micromolar concentrations.