Synthesis and absolute configuration of novel N,O-psiconucleosides using (R)-N-phenylpantolactam as a resolution agent
Camps, Pelayo × Gómez, Tània Munoz-Torrero, Diego Rull, Jordi Sánchez, Laura Boschi, Francesca Comes-Franchini, Mauro Ricci, Alfredo Calvet, Teresa Font-Bardia, Merce De Clercq, Erik Naesens, Lieve #
American Chemical Society
Journal of Organic Chemistry vol:73 issue:17 pages:6657-6665
A series of novel N, O-psiconucleosides has been prepared in both enantiomeric forms by resolution of an advanced racemic synthetic intermediate using ( R)- N-phenylpantolactam as a chiral resolution agent. The absolute configuration of all of these compounds has been unequivocally established by chemical correlation with the novel ( R)- or ( S)-1-methyl-5-phenylpyrrolidine-2,3-dione, prepared from the known ( R)- and ( S)-1-methyl-5-phenylpyrrolidin-2-one, respectively.