Title: Synthesis and absolute configuration of novel N,O-psiconucleosides using (R)-N-phenylpantolactam as a resolution agent
Authors: Camps, Pelayo ×
Gómez, Tània
Munoz-Torrero, Diego
Rull, Jordi
Sánchez, Laura
Boschi, Francesca
Comes-Franchini, Mauro
Ricci, Alfredo
Calvet, Teresa
Font-Bardia, Merce
De Clercq, Erik
Naesens, Lieve #
Issue Date: Sep-2008
Publisher: American Chemical Society
Series Title: Journal of Organic Chemistry vol:73 issue:17 pages:6657-6665
Abstract: A series of novel N, O-psiconucleosides has been prepared in both enantiomeric forms by resolution of an advanced racemic synthetic intermediate using ( R)- N-phenylpantolactam as a chiral resolution agent. The absolute configuration of all of these compounds has been unequivocally established by chemical correlation with the novel ( R)- or ( S)-1-methyl-5-phenylpyrrolidine-2,3-dione, prepared from the known ( R)- and ( S)-1-methyl-5-phenylpyrrolidin-2-one, respectively.
ISSN: 0022-3263
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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