Title: The vagus nerve is involved in the anorexigenic effect of simmondsin in the rat
Authors: Flo, Gerda ×
Van Boven, Maurits
Vermaut, S
Daenens, Paul
Decuypere, Eddy
Cokelaere, Marnix #
Issue Date: Apr-2000
Series Title: Appetite vol:34 issue:2 pages:147-51
Abstract: Simmondsin, 2-(cyanomethylene)-3 hydroxy 4,5 dimethoxy cyclohexyl beta-D-glucoside, from jojoba meal reduces food intake in rats. We investigated the mechanism of action simmondsin, by studying the effects of fasting or of vagotomy on the food intake reduction. The food intake reduction was significantly less in fasted rats than in non-fasted rats. The reduction of food intake was also significantly diminished after vagotomy. The results of the present experiments suggest that simmondsin reduces intake of food in rats through the augmentation of satiety, in part vagally mediated.
ISSN: 0195-6663
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Faculty of Medicine, Campus Kulak Kortrijk
Division of Livestock-Nutrition-Quality (-)
Interdisciplinary Research Facility Life Sciences, Campus Kulak Kortrijk
Toxicology and Pharmacology
× corresponding author
# (joint) last author

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