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Title: Quantitative analysis of quaternary ammonium antiseptics using thin-layer densitometry
Authors: Paesen, J ×
Quintens, Ivo
Thoithi, G
Roets, Eugene
Reybrouck, Gerald
Hoogmartens, Jos #
Issue Date: Aug-1994
Series Title: Journal of Chromatography A vol:677 issue:2 pages:377-84
Abstract: A thin-layer chromatography method for quantitative analysis of quaternary ammonium antiseptics is described. Silanized silica gel was used as the stationary phase. The mobile phase consisted of methanol-25% (m/v) sodium acetate solution-acetone (65:35:20). The method is able to separate the chain homologues of benzalkonium chloride, cetylpyridinium chloride and cetrimide. Detection was performed using a colour reaction with potassium triiodide solution. The different homologues were quantified using UV densitometry at 400 nm. A number of commercial samples was analysed using this method. From the results it appears that it is worthwhile to have a limit test for the composition of quaternary ammonium antiseptics in pharmacopoeial monographs, the more so as the antibacterial activity depends on it.
ISSN: 0021-9673
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmaceutical Analysis
Environment and Health - miscellaneous
× corresponding author
# (joint) last author

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