Title: Presenilins: Members of the {gamma}-Secretase Quartets, But Part-Time Soloists Too
Authors: Wakabayashi, Tomoko
De Strooper, Bart # ×
Issue Date: Aug-2008
Publisher: International Union of Physiological Sciences
Series Title: Physiology vol:23 pages:194-204
Abstract: The presenilins in combination with other proteins generate different gamma-secretases, which are involved in the regulated intramembrane proteolysis of a variety of proteins. Understanding the specificity and regulation of these proteases will potentially lead to novel therapeutics for Alzheimer's disease and cancer. Presenilins appear also to exert additional functions outside of the gamma-secretase quartets, which needs further investigation.
ISSN: 1548-9213
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Genetics Section (-)
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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