Title: The binding of gitoxin to human plasma proteins
Authors: Verbeke, Norbert ×
Pellegrin, P
Vienne, A
Lesne, M #
Issue Date: 1979
Publisher: Springer verlag
Series Title: European journal of clinical pharmacology vol:16 issue:5 pages:341-344
Abstract: The binding of gitoxin, digitoxin and digoxin to human plasma proteins was measured by ultracentrifugation and equilibrium dialysis. At concentrations in the range of therapeutic plasma levels, protein binding amounted, respectively, to 85, 92 and 20%, the last two values being consistent with data reported in the literature. The affinity of purified human albumin was not significantly different for the three cardiac glycosides tested. No other protein than albumin was found to bind gitoxin in human plasma.
ISSN: 0031-6970
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Drug Delivery and Disposition
× corresponding author
# (joint) last author

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