Title: Heterocyclic modifications of oligonucleotides and antisense technology
Authors: Herdewijn, Piet # ×
Issue Date: Aug-2000
Publisher: Mary Ann Liebert
Series Title: Antisense & Nucleic Acid Drug Development vol:10 issue:4 pages:297-310
Abstract: Modification of the heterocyclic moiety of oligonucleotides has led to the discovery of potent antisense compounds. This review describes the physicochemical factors that are responsible for duplex stabilization through base modification. A summary is given of the different heterocyclic modifications that can be used to beneficially influence this duplex stability. The biologic activity of base-modified oligonucleotides is described, and the different factors that are important for obtaining in vivo antisense activity with heterocyclic-modified oligonucleotides are summarized.
ISSN: 1087-2906
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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