Title: Quantitative analysis of chlortetracycline and related substances by high-performance liquid chromatography
Authors: Khan, N H ×
Roets, Eugene
Hoogmartens, Jos
Vanderhaeghe, Hubert #
Issue Date: Jan-1989
Series Title: Journal of pharmaceutical and biomedical analysis vol:7 issue:3 pages:339-53
Abstract: Isocratic high-performance liquid chromatography on Zorbax C8 7 microns allows quantitative determination of chlortetracycline, 4-epichlortetracycline, tetracycline, demethylchlortetracycline and isochlortetracycline using a mobile phase containing dimethylsulphoxide, 1 M perchloric acid and water (35:5:60). The minor impurities anhydrochlortetracycline and 4-epianhydrochlortetracycline, which are more strongly retained can be determined using a second isocratic system with a mobile phase containing more organic modifier. The method has been used for the comparison of official standards and for the analysis of a number of commercial samples.
ISSN: 0731-7085
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmaceutical Analysis
Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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