Title: Mucosal response in African catfish after administration of Vibrio anguillarum O2 antigens via different routes
Authors: Vervarcke, Stefaan ×
Ollevier, Frans
Kinget, Renaat
Michoel, Armand #
Issue Date: Feb-2005
Series Title: Fish & shellfish immunology vol:18 issue:2 pages:125-33
Abstract: The aim of this study was to investigate the possibility of mucosal vaccination in African catfish (Clarias gariepinus) with Vibrio anguillarum O2 bacterins. The antigen was administered via different routes: anal intubation, oral administration, intraperitoneal injection and immersion. To monitor the antigen uptake, a competitive ELISA was used. The antibody response was measured using an indirect ELISA. Increased antibody levels were found in bile and mucus upon anal intubation, which was not the case after intraperitoneal injection. The data indicate that oral vaccination of fish may be possible when antigens can reach the second gut segment in sufficient quantities and in the right form as confirmed by the recorded substantial induction of systemic and mucosal immunity. The results obtained are a strong indication for mucosal immune response and the two compartmental models for immune response in fish.
ISSN: 1050-4648
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Drug Delivery and Disposition
Ecology, Evolution and Biodiversity Conservation Section
× corresponding author
# (joint) last author

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