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Title: Novel in vivo roles of the receptor guanylate cyclase, Gyc76C
Authors: Guo, A
Cabrero, P
Mertens, Inge
Schoofs, Liliane
Davies, S
Dow, J #
Issue Date: Jul-2008
Publisher: Elsevier science inc
Host Document: Comparative biochemistry and physiology a-molecular & integrative physiology vol:150 issue:3 pages:S136-S136
Conference: Annual Main Meeting of the Society of Experimental Biology location:Marseille, France date:6th - 10th July 2008
Abstract: Membrane receptor guanylate cyclases (rGCs) are homodimeric, ligand-binding transmembrane proteins which catalyse the formation cGMP. The Drosophila genome encodes at least seven receptor and receptor-like GCs including Gyc76C.

In the adult fly, expression of Gyc76c is highest in epithelial tissues, including Malpighian (renal) tubules and in ovary (flyatlas.org). In-situ hybridisation studies in intact tubules reveal that Gyc76c is expressed in principal cells of main segment.

Ablation of Gyc76c via RNAi in tubule principal cells results in lethality of adult flies two days post-eclosion. By contrast, ablation of Gyc76c in either tubule stellate cells or in the CNS does not result in adult lethality. No ligand has yet been identified for any member of the rGC family in Drosophila, nor in insects. Here we describe a screen for peptide modulators of Gyc76c function; and indicate a novel peptide ligand for Gyc76C, which impacts on Malpighian tubule function.
ISSN: 1095-6433
Publication status: published
KU Leuven publication type: IMa
Appears in Collections:Animal Physiology and Neurobiology Section - miscellaneous
# (joint) last author

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