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Title: The first potassium channel toxin from the venom of the Iranian scorpion Odonthobuthus doriae
Authors: Abdel Mottaleb, Yousra
Clynen, Elke
Jalali, Amir
Bosmans, Frank
Vatanpour, Hossein
Schoofs, Liliane
Tytgat, Jan # ×
Issue Date: Nov-2006
Publisher: Elsevier on behalf of the Federation of European Biochemical Societies
Series Title: FEBS Letters vol:580 issue:26 pages:6254-6258
Abstract: The very first member of K(+) channels toxins from the venom of the Iranian scorpion Odonthobuthus doriae (OdK1) was purified, sequenced and characterized physiologically. OdK1 has 29 amino acids, six conserved cysteines and a pI value of 4.95. Based on multiple sequence alignments, OdK1 was classified as alpha-KTx 8.5. The pharmacological effects of OdK1 were studied on six different cloned K(+) channels (vertebrate Kv1.1-Kv1.5 and Shaker IR) expressed in Xenopus laevis oocytes. Interestingly, OdK1 selectively inhibited the currents through Kv1.2 channels with an IC50 value of 183+/-3 nM but did not affect any of the other channels.
URI: 
ISSN: 0014-5793
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Toxicology and Pharmacology
Animal Physiology and Neurobiology Section - miscellaneous
× corresponding author
# (joint) last author

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