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Title: OdK2, a Kv1.3 channel-selective toxin from the venom of the Iranian scorpion Odonthobuthus doriae
Authors: Abdel-Mottaleb, Yousra ×
Vandendriessche, Thomas
Clynen, Elke
Landuyt, Bart
Jalali, Amir
Vatanpour, Hossein
Schoofs, Liliane
Tytgat, Jan #
Issue Date: Jun-2008
Series Title: Toxicon vol:51 issue:8 pages:1424-30
Abstract: The first Kv1.3 channel-selective toxin from the venom of the Iranian scorpion Odonthobuthus doriae (OdK2) was purified, sequenced and characterized physiologically. OdK2 consists of 38 amino acids, including six conserved cysteine and a C-terminal lysine residue, as revealed by the unique use of a quadrupole ion cyclotron resonance Fourier-transform mass spectrometer. Based on multiple sequence alignments, OdK2 was classified as alpha-KTX3.11. The pharmacological effects of OdK2 were studied on a panel of eight different cloned K(+) channels (vertebrate Kv1.1-Kv1.6, Shaker IR and hERG) expressed in Xenopus laevis oocytes. Interestingly, OdK2 selectively inhibits the currents through Kv1.3 channels with an IC50 value of 7.2+/-2.7nM.
URI: 
ISSN: 0041-0101
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Animal Physiology and Neurobiology Section - miscellaneous
Division of Mechatronics, Biostatistics and Sensors (MeBioS)
Toxicology and Pharmacology
× corresponding author
# (joint) last author

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