ITEM METADATA RECORD
Title: Sea anemone venom as a source of insecticidal peptides acting on voltage-gated Na(+) channels
Authors: Bosmans, Frank ×
Tytgat, Jan #
Issue Date: 15-Mar-2007
Publisher: Elsevier
Series Title: Toxicon vol:49 issue:4 pages:550-560
Abstract: Sea anemones produce a myriad of toxic peptides and proteins of which a large group acts on voltage-gated Na(+) channels. However, in comparison to other organisms, their venoms and toxins are poorly studied. Most of the known voltage-gated Na(+) channel toxins isolated from sea anemone venoms act on neurotoxin receptor site 3 and inhibit the inactivation of these channels. Furthermore, it seems that most of these toxins have a distinct preference for crustaceans. Given the close evolutionary relationship between crustaceans and insects, it is not surprising that sea anemone toxins also profoundly affect insect voltage-gated Na(+) channels, which constitutes the scope of this review. For this reason, these peptides can be considered as insecticidal lead compounds in the development of insecticides.
ISSN: 0041-0101
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Toxicology and Pharmacology
× corresponding author
# (joint) last author

Files in This Item:
File Status SizeFormat
Sea anemone venom as a source of insecticidal peptides acting on voltage-gated Na+ channels.pdf Published 1136KbAdobe PDFView/Open

 


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science