Title: Image-derived input function for [11C]flumazenil kinetic analysis in human brain
Authors: Sanabria-Bohórquez, Sandra M ×
Maes, Alex
Dupont, Patrick
Bormans, Guy
de Groot, Tjibbe
Coimbra, Alexandre
Eng, WaiSi
Laethem, Tine
De Lepeleire, Inge
Gambale, Jay
Vega, Jose M
Burns, H Donald #
Issue Date: Mar-2003
Publisher: Elsevier Science
Series Title: Molecular imaging and biology vol:5 issue:2 pages:72-8
Abstract: PURPOSE: We describe a method for analysis of [11C]flumazenil data using an input curve directly derived from the positron emission tomography (PET) images. PROCEDURE: The shape of the tracer plasma curve was obtained from the product of the intact flumazenil fraction in plasma in six arterial samples and the internal carotid artery time-activity curve (TAC). The resulting curve was calibrated using the [11C]flumazenil concentration in three of the six samples. The curve peak was recovered by adding an exponential function to the scaled curve whose parameters were estimated from simultaneous fittings of several tissue TACs assuming that all regions share the same input. RESULTS: Good agreement was found between the image-derived and the experimental plasma curves in six subjects. Distribution volumes were highly correlated with linear regression slope and intercept values between [0.94, 1.03] and [-0.10, 0.16], respectively. CONCLUSION: The proposed method is suitable for benzodiazepine receptor quantification requiring only a few blood samples.
ISSN: 1536-1632
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Nuclear Medicine & Molecular Imaging
Radiopharmaceutical Research
Research Group Experimental Neurology
Laboratory for Cognitive Neurology
× corresponding author
# (joint) last author

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