Title: Successful kinase bypass with new acyclovir phosphoramidate prodrugs
Authors: McGuigan, Christopher ×
Derudas, Marco
Bugert, Joachim J
Andrei, Graciela
Snoeck, Robert
Balzarini, Jan #
Issue Date: Aug-2008
Publisher: Pergamon Press
Series Title: Bioorganic & Medicinal Chemistry Letters vol:18 issue:15 pages:4364-4367
Abstract: Novel phosphoramidates of acyclovir have been prepared and evaluated in vitro against acyclovir-sensitive and -resistant herpes simplex virus (HSV) types 1 and 2 and varicella-zoster virus (VZV). Unlike the parent nucleoside these novel phosphate prodrugs retain antiviral potency versus the ACV-resistant virus strain, suggesting an efficient bypass of the viral thymidine kinase.
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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