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Title: Amnioinfusion with Hartmann's solution: a safe distention medium for endoscopic fetal surgery in the ovine model
Authors: Evrard, V A ×
Verbeke, Kristin
Peers, K H
Luks, F I
Lerut, A
Vandenberghe, Katleen
Deprest, Jan #
Issue Date: 1997
Publisher: S. Karger
Series Title: Fetal Diagnosis and Therapy vol:12 issue:3 pages:188-92
Abstract: In this study, we have investigated the maternal effects of distending the uterine cavity with Hartmann's solution in 2nd trimester equivalent pregnant sheep. In 7 pregnant ewes, double endoscopic cannulation of the amniotic cavity was performed under general anesthesia, and 1 liter of Hartmann's solution at 38 degrees C, radiolabeled with 99mTc-red blood cells, was infused. Maternal central venous pressure, hematocrit, serum and amniotic fluid osmolarity, and amniotic fluid volume were measured at nine time points within a 2-hour period. Over this time interval, no significant fluid shift to the maternal compartment was observed. We detected no adsorption of radioactivity to the fetus or membranes, and no diffusion of radioactivity to maternal or fetal tissues was noticed. We conclude from these experiments that following double cannulation and intra-amniotic infusion of Hartmann's solution into the 2nd-trimester pregnant ovine uterus, no significant shift of fluid to the maternal compartment was observed over a 2-hour time period.
ISSN: 1015-3837
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
Foetal Medicine Section (-)
× corresponding author
# (joint) last author

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