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Title: Beta-blockers: once or three times a day?
Authors: Reybrouck, Tony ×
Amery, A
Fagard, Robert
Jousten, P
Lijnen, Paul
Meulepas, Ernest #
Issue Date: 1978
Series Title: British medical journal vol:1 issue:6124 pages:1386-8
Abstract: In a double-blind, crossover trial 16 hypertensive patients were treated, in random order, with placebo, metoprolol 300 mg in a single daily dose, or metoprolol 300 mg/day in three doses. Both therapeutic regimens produced detectable plasma metoprolol concentrations and appreciable beta-blockade, estimated from exercise tachycardia, throughout the day. Fluctuations throughout the day in plasma drug concentrations and degree of beta-blockade were insignificant on the thrice-daily regimen, but they varied considerably on the single-dose regimen. Both therapeutic regimens also significantly lowered blood pressure throughout the day. Although the thrice-daily regimen again tended to produce a stronger and less fluctuating hypotensive action, the differences in hypotensive effect between the two regimens were not statistically significant. A single-dose of 300 mg of metoprolol can therefore be recommended if the only aim is to reduce blood pressure but not if a steady degree of beta-blockade is needed.
ISSN: 0007-1447
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hypertension and Cardiovascular Epidemiology
Research Group for Cardiovascular and Respiratory Rehabilitation
× corresponding author
# (joint) last author

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