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Title: Translocation 2;11 in a fibroma of tendon sheath
Authors: Dal Cin, Paola ×
Sciot, Raphael
De Smet, Luc
Van den Berghe, Herman #
Issue Date: May-1998
Series Title: Histopathology vol:32 issue:5 pages:433-5
Abstract: AIMS: To determine whether fibromas of tendon sheath represent a reactive fibrosing process or whether they are neoplastic, we investigated the chromosomes of the proliferating cells. A clonally occurring karyotypic abnormality would be an argument in favour of these fibromas being neoplastic. METHODS AND RESULTS: A biopsy specimen of a fibroma of tendon sheath was cultured after collagenase exposure leading to dissociation of the tissue. The cultured cells were harvested after 4 days and chromosome analysis done according to standard procedures. Ten out of 20 karyotyped cells showed an identical chromosome abnormality characterized by a t(2;11)(q31-32;q12). The other 10 cells showed a normal 46,XX karyotype. CONCLUSION: The clonally occurring chromosome abnormality found in this fibroma of tendon sheath suggests that this proliferation is neoplastic and not a reactive fibrosing process.
ISSN: 0309-0167
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Cell & Tissue Research
Research Group for Musculoskeletal Rehabilitation
Clinical Genetics Section (-)
× corresponding author
# (joint) last author

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