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Title: Cutaneous sclerosing perineurioma with cryptic NF2 gene deletion
Authors: Sciot, Raphael ×
Dal Cin, Paola
Hagemeijer-Hausman, Anne
De Smet, Luc
Van Damme, Boudewijn
Van den Berghe, Herman #
Issue Date: Jul-1999
Series Title: The American journal of surgical pathology vol:23 issue:7 pages:849-53
Abstract: Sclerosing perineurioma is a recently described variant of perineurioma that characteristically occurs in the fingers and palms of young adults. We report a cutaneous sclerosing perineurioma with preservation of the axons and Schwann cells in the center of the whorls of perineurial cells, a feature that previously was reported to be typically absent in these lesions. Additionally, clonal chromosomal abnormalities of chromosome 10 and a cryptic deletion of the 5'BCR and NF2 loci on chromosome 22 were present. These findings further support the hypothesis that a gene on chromosome 22 may play a role in the pathogenesis of perineurioma. The NF2 gene is a logical candidate because of its involvement in other nerve sheath tumors.
ISSN: 0147-5185
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Cell & Tissue Research
Research Group for Musculoskeletal Rehabilitation
Department of Human Genetics - miscellaneous
Clinical Genetics Section (-)
× corresponding author
# (joint) last author

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