Title: Involvement of hyperprolinemia in cognitive and psychiatric features of the 22q11 deletion syndrome
Authors: Raux, Grégory ×
Bumsel, Emilie
Hecketsweiler, Bernadette
van Amelsvoort, Therese
Zinkstok, Janneke
Manouvrier-Hanu, Sylvie
Fantini, Carole
Brévière, Georges-Marie M
Di Rosa, Gabriella
Pustorino, Giuseppina
Vogels, Annick
Swillen, Ann
Legallic, Solenn
Bou, Jacqueline
Opolczynski, Gaelle
Drouin-Garraud, Valérie
Lemarchand, Marie
Philip, Nicole
Gérard-Desplanches, Aude
Carlier, Michèle
Philippe, Anne
Nolen, Marie Christine
Heron, Delphine
Sarda, Pierre
Lacombe, Didier
Coizet, Cyril
Alembik, Yves
Layet, Valérie
Afenjar, Alexandra
Hannequin, Didier
Demily, Caroline
Petit, Michel
Thibaut, Florence
Frebourg, Thierry
Campion, Dominique #
Issue Date: Jan-2007
Publisher: IRL Press
Series Title: Human Molecular Genetics vol:16 issue:1 pages:83-91
Abstract: Microdeletions of the 22q11 region, responsible for the velo-cardio-facial syndrome (VCFS), are associated with an increased risk for psychosis and mental retardation. Recently, it has been shown in a hyperprolinemic mouse model that an interaction between two genes localized in the hemideleted region, proline dehydrogenase (PRODH) and catechol-o-methyl-transferase (COMT), could be involved in this phenotype. Here, we further characterize in eight children the molecular basis of type I hyperprolinemia (HPI), a recessive disorder resulting from reduced activity of proline dehydrogenase (POX). We show that these patients present with mental retardation, epilepsy and, in some cases, psychiatric features. We next report that, among 92 adult or adolescent VCFS subjects, a subset of patients with severe hyperprolinemia has a phenotype distinguishable from that of other VCFS patients and reminiscent of HPI. Forward stepwise multiple regression analysis selected hyperprolinemia, psychosis and COMT genotype as independent variables influencing IQ in the whole VCFS sample. An inverse correlation between plasma proline level and IQ was found. In addition, as predicted from the mouse model, hyperprolinemic VCFS subjects bearing the Met-COMT low activity allele are at risk for psychosis (OR = 2.8, 95% CI = 1.04-7.4). Finally, from the extensive analysis of the PRODH gene coding sequence variations, it is predicted that POX residual activity in the 0-30% range results into HPI, whereas residual activity in the 30-50% range is associated either with normal plasma proline levels or with mild-to-moderate hyperprolinemia.
ISSN: 0964-6906
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group for Adapted Physical Activity and Psychomotor Rehabilitation
Department of Human Genetics - miscellaneous
Clinical Genetics Section (-)
× corresponding author
# (joint) last author

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