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Title: Survival after a lethal dose of arsenic trioxide
Authors: Vantroyen, Barbara ×
Heilier, J F
Meulemans, Agnes
Michels, Arnold
Buchet, J P
Vanderschueren, Steven
Haufroid, V
Sabbe, Marc #
Issue Date: Jan-2004
Series Title: Journal of toxicology. Clinical toxicology vol:42 issue:6 pages:889-95
Abstract: A case of a 27-year-old woman who ingested 9000 mg arsenic trioxide (As2O3) is reported. Classical symptoms of an acute arsenicum (As) poisoning such as gastrointestinal cramps, vomiting, diarrhea, ECG changes and disturbed liver function tests were observed. The absorption of the ingested As was minimalized by a continuous gastric irrigation with highly concentrated NaHCO3 and intestinal cleansing with NaHCO3 and polyethyleneglycol was performed. Forced diuresis, BAL (2,3-dimercaptopropanol) and DMSA (meso-2,3-dimercaptosuccinic acid) were started and therapy to enhance the formation of methylated As derivatives, which are potentially less toxic and which can be excreted more easily, was then administered. The patient survived this massive dose of ingested inorganic As with only polyneuropathy one year later.
ISSN: 0731-3810
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Emergency Medicine
Department of Rehabilitation Sciences - miscellaneous
Laboratory for Clinical Infectious and Inflammatory Disorders
× corresponding author
# (joint) last author

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