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Title: Caffeine counteracts the ergogenic action of muscle creatine loading
Authors: Vandenberghe, K ×
Gillis, Nanna
Van Leemputte, Marc
Van Hecke, Paul
Vanstapel, Florent
Hespel, Peter #
Issue Date: Feb-1996
Series Title: Journal of applied physiology (Bethesda, Md. : 1985) vol:80 issue:2 pages:452-7
Abstract: This study aimed to compare the effects of oral creatine (Cr) supplementation with creatine supplementation in combination with caffeine (Cr+C) on muscle phosphocreatine (PCr) level and performance in healthy male volunteers (n = 9). Before and after 6 days of placebo, Cr (0.5 g x kg-1 x day-1), or Cr (0.5 g x kg-1 x day-1) + C (5 mg x kg-1 x day-1) supplementation, 31P-nuclear magnetic resonance spectroscopy of the gastrocnemius muscle and a maximal intermittent exercise fatigue test of the knee extensors on an isokinetic dynamometer were performed. The exercise consisted of three consecutive maximal isometric contractions and three interval series of 90, 80, and 50 maximal voluntary contractions performed with a rest interval of 2 min between the series. Muscle ATP concentration remained constant over the three experimental conditions. Cr and Cr+C increased (P < 0.05) muscle PCr concentration by 4-6%. Dynamic torque production, however, was increased by 10-23% (P < 0.05) by Cr but was not changed by Cr+C. Torque improvement during Cr was most prominent immediately after the 2-min rest between the exercise bouts. The data show that Cr supplementation elevates muscle PCr concentration and markedly improves performance during intense intermittent exercise. This ergogenic effect, however, is completely eliminated by caffeine intake.
ISSN: 8750-7587
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Radiology
Laboratory of Clinical Bacteriology and Mycology
Exercise Physiology Research Group
Biomedical Quality Assurance Research Unit
× corresponding author
# (joint) last author

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