The present experiment addressed the time course of corticospinal excitability changes following interventional muscle tendon vibration. Using transcranial magnetic stimulation, motor evoked potentials of the flexor carpi radialis and extensor carpi radialis brevis muscle were recorded for a period of 60 min after cessation of vibration (80 Hz, 0.5 mm, 30 min) to the distal wrist flexor tendons. A delayed corticospinal excitability increase in both the vibrated and non-vibrated antagonistic muscle was observed, with lasting levels of facilitation for the latter. No changes were observed following interventional cutaneous vibration. These results underscore a facilitatory influence of prolonged Ia-afferent activation on corticospinal excitability. Findings are discussed in light of recent advances in promoting motor recovery after brain injury by somatosensory stimulation.