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Keywords:

Adrenergic beta-Antagonists, Humans, Male, Receptors, Adrenergic, beta, Renin, Science & Technology, Life Sciences & Biomedicine, Medicine, General & Internal, General & Internal Medicine, 11 Medical and Health Sciences, 32 Biomedical and clinical sciences, 42 Health sciences

Abstract:

To the Editor: In the June 14 issue, Lefkowitz et al. reported that the stimulation of renin release is mediated by β2-receptors.1 In the past the relative role of β1- and β2-receptors in renin secretion was difficult to study since the pharmacologic tools had poor selectivity; the β-blockers used often had β1- and β2-blocking action, and the agonists showed low selectivity. Furthermore, the methods of renin determination differed from one study to another: some measured the plasma renin activity, others the plasma renin concentration. This led to confusion, and the. © 1985, Massachusetts Medical Society. All rights reserved.