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Title: Creatine supplementation in Huntington's disease: a placebo-controlled pilot trial
Authors: Verbessem, Patricia
Lemiere, Jurgen
Op 't Eijnde, Bert
Swinnen, Stephan
Vanhees, Luc
Van Leemputte, Marc
Hespel, Peter
Dom, RenĂ© # ×
Issue Date: Oct-2003
Publisher: Advanstar Communications
Series Title: Neurology vol:61 pages:925-930
Abstract: OBJECTIVE: To evaluate the effect of creatine (Cr) supplementation (5 g/day) in Huntington's disease (HD). METHODS: A 1-year double-blind placebo-controlled study was performed in 41 patients with HD (stage I through III). At baseline and after 6 and 12 months, the functional, neuromuscular, and cognitive status of the patients was assessed by a test battery that consisted of 1) the Unified Huntington's Disease Rating Scale (UHDRS), 2) an exercise test on an isokinetic dynamometer to assess strength of the elbow flexor muscles, 3) a maximal exercise test on a bicycle ergometer to evaluate cardiorespiratory fitness, and 4) a test to assess bimanual coordination ability. Following the baseline measurements, the subjects were assigned to either a creatine (n = 26) or a placebo group (n = 15). RESULTS: Scores on the functional checklist of the UHDRS (p < 0.05), maximal static torque (p < 0.05), and peak oxygen uptake (p < 0.05) decreased from the start to the end of the study, independent of the treatment received. Cognitive functioning, bimanual coordination ability, and general motor function (total motor scale, UHDRS) did not change from baseline to 1 year in either group. CONCLUSION: One year of Cr intake, at a rate that can improve muscle functional capacity in healthy subjects and patients with neuromuscular disease (5 g/day), did not improve functional, neuromuscular, and cognitive status in patients with stage I to III HD.
ISSN: 0028-3878
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Kinesiology - miscellaneous
Exercise Physiology Research Group
Research Group for Cardiovascular and Respiratory Rehabilitation
Faculty of Medicine - miscellaneous
Movement Control & Neuroplasticity Research Group
Forensic Dentistry
× corresponding author
# (joint) last author

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