Oral creatine supplementation in humans does not elevate urinary excretion of the carcinogen N-nitrososarcosine
Derave, Wim × Vanden Eede, Els Hespel, Peter Carmella, Steven G Hecht, Stephen S #
Nutrition (Burbank, Los Angeles County, Calif.) vol:22 issue:3 pages:332-3
OBJECTIVE: Creatine is a popular oral supplement in athletes and may have therapeutical potential in neuromuscular diseases. It has been hypothesized that creatine ingestion can lead to increased formation of the carcinogen N-nitrososarcosine. METHODS: We investigated in a double-blind, placebo-controlled study the urinary excretion of N-nitrososarcosine after 1-wk high-dose (20 g/d) and 20-wk low-dose (5 g/d) creatine supplementation in healthy humans. RESULTS AND CONCLUSION: Creatine ingestion does not systematically increase urinary N-nitrososarcosine excretion.