Title: Reversine-treated fibroblasts acquire myogenic competence in vitro and in regenerating skeletal muscle
Authors: Anastasia, Luigi ×
Sampaolesi, Maurilio
Papini, Nadia
Oleari, Diego
Lamorte, Giuseppe
Tringali, Cristina
Monti, Eugenio
Galli, Daniela
Tettamanti, Guido
Cossu, Giulio
Venerando, Bruno #
Issue Date: Dec-2006
Series Title: Cell Death and Differentiation vol:13 issue:12 pages:2042-2051
Abstract: Stem cells hold a great potential for the regeneration of damaged tissues in cardiovascular or musculoskeletal diseases. Unfortunately, problems such as limited availability, control of cell fate, and allograft rejection need to be addressed before therapeutic applications may become feasible. Generation of multipotent progenitors from adult differentiated cells could be a very attractive alternative to the limited in vitro self-renewal of several types of stem cells. In this direction, a recently synthesized unnatural purine, named reversine, has been proposed to induce reversion of adult cells to a multipotent state, which could be then converted into other cell types under appropriate stimuli. Our study suggests that reversine treatment transforms primary murine and human dermal fibroblasts into myogenic-competent cells both in vitro and in vivo. Moreover, this is the first study to demonstrate that plasticity changes arise in primary mouse and human cells following reversine exposure.
ISSN: 1350-9047
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Interdepartemental Stem Cell Institute (-)
× corresponding author
# (joint) last author

Files in This Item:
File Status SizeFormat
Anastasia - Cell Death and Differentation - 2006.pdf Published 504KbAdobe PDFView/Open


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science