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Title: Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors
Authors: Minetti, G. C ×
Colussi, C
Adami, R
Serra, C
Mozzetta, C
Parente, V
Fortuni, S
Straino, S
Sampaolesi, Maurilio
Di Padova, M
Illi, B
Gallinari, P
Steinkuehler, C
Capogrossi, M. C
Sartorelli, V
Bottinelli, R
Gaetano, C
Puri, P. L #
Issue Date: Oct-2006
Series Title: Nature Medicine vol:12 issue:10 pages:1147-1150
Abstract: Pharmacological interventions that increase myofiber size counter the functional decline of dystrophic muscles(1,2). We show that deacetylase inhibitors increase the size of myofibers in dystrophin-deficient (MDX) and alpha-sarcoglycan (alpha-SG)-deficient mice by inducing the expression of the myostatin antagonist follistatin(3) in satellite cells. Deacetylase inhibitor treatment conferred on dystrophic muscles resistance to contraction-coupled degeneration and alleviated both morphological and functional consequences of the primary genetic defect. These results provide a rationale for using deacetylase inhibitors in the pharmacological therapy of muscular dystrophies.
ISSN: 1078-8956
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Interdepartemental Stem Cell Institute (-)
× corresponding author
# (joint) last author

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