Title: Transmitting on actin: synaptic control of dendritic architecture
Authors: Schubert, Vanessa
Dotti, Carlos #
Issue Date: Jan-2007
Series Title: Journal of Cell Science vol:120 issue:2 pages:205-212
Abstract: Excitatory synaptic transmission in the central nervous system mainly takes place at dendritic spines, highly motile protrusions on the dendritic surface. Depending on the stimuli received, dendritic spines undergo rapid actin-based changes in their morphology. This plasticity appears to involve signaling through numerous proteins that control the organization of the actin cytoskeleton ( actin regulators). At least in part, recruitment and activation of these depends on neurotransmitter receptors at the post-synapse, which directly link neurotransmission to changes in dendritic spine architecture. However, other, non-neurotransmitter-receptors present at dendritic spines also participate. It is likely that several receptor types can control the activity of a single actin-regulatory pathway and it is the complex integration of numerous signals that determines the overall architecture of a dendritic spine.
ISSN: 0021-9533
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Genetics Section (-)
Department of Human Genetics - miscellaneous
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science