Title: Changes in membrane trafficking and actin dynamics during axon formation in cultured hippocampal neurons
Authors: Bradke, F
Dotti, Carlos #
Issue Date: Jan-2000
Series Title: Microscopy Research and Technique vol:48 issue:1 pages:3-11
Abstract: Neurons begin to polarize when one of the neurites becomes the axon. Hippocampal neurons in cell culture have a sharp transition between their unpolarized and polarized stage revealed by the rapid growth of the future axon. Recent progress shows that both a cytoplasmic membrane flow and actin dynamics govern axon formation, and thereby initial neuronal polarization. We here review these mechanisms, evaluate their physiological role, and show similarities to the transient polarization of migrating fibroblasts. Finally, we present a model how actin dynamics and vectorial membrane flow may interact to achieve axon formation. (C) 2000 Wiley-Liss, Inc.
ISSN: 1059-910X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Genetics Section (-)
Department of Human Genetics - miscellaneous
# (joint) last author

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