Title: Imaging of gynecological disease (3): clinical and ultrasound characteristics of granulosa cell tumors of the ovary
Authors: Van Holsbeke, C ×
Domali, E
Holland, T K
Achten, Ruth
Testa, A C
Valentin, L
Jurkovic, D
Moerman, Philippe
Timmerman, Dirk #
Issue Date: Apr-2008
Publisher: Blackwell Science
Series Title: Ultrasound in Obstetrics & Gynecology vol:31 issue:4 pages:450-6
Abstract: OBJECTIVES: To describe the clinical and ultrasound characteristics of granulosa cell tumors (GCTs) of the ovary, and to define the ultrasound appearance of GCTs based on pattern recognition. METHODS: Databases of four gynecological ultrasound centers were searched to identify patients with histologically proven GCTs who had undergone a standard preoperative ultrasound examination. RESULTS: A total of 23 women with confirmed GCT were identified. Twelve (52%) women were postmenopausal, nine (39%) were of fertile age and two (9%) were prepubertal. Clinical symptoms were abdominal distension (7/23, 30%), pain (5/23, 22%) and irregular vaginal bleeding (6/23, 26%). Seven patients (30%) were asymptomatic. Endometrial pathology was found in 54% (7/13) of the patients from whom endometrial biopsies were taken. On ultrasound scan 12/23 (52%) masses were multilocular-solid, 9/23 (39%) were purely solid, one mass (4%) was unilocular-solid and one mass was multilocular (4%). Multilocular and multilocular-solid cysts typically contained large numbers of small locules (> 10). The echogenicity of the cyst content was most often mixed (6/16, 38%) or low level (7/16, 44%). Papillary projections were found in only four women (17%). The GCTs were large tumors with a median largest diameter of 102 (range, 37-242) mm and manifested moderate or high color content at color Doppler examination (color score 3 in 13/23 tumors (57%); color score 4 in 8/23 tumors (35%)). CONCLUSIONS: At ultrasound examination, most GCTs are large multilocular-solid masses with a large number of locules, or solid tumors with heterogeneous echogenicity of the solid tissue. Hemorrhagic components are common and increased vascularity is demonstrated at color/power Doppler ultrasound examination. The hyperestrogenic state that is created by the tumor often causes endometrial pathology with bleeding problems as a typical associated symptom.
ISSN: 0960-7692
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Cell & Tissue Research
Gynaecological Imaging Section (-)
Section Woman - Miscellaneous (-)
× corresponding author
# (joint) last author

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